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HCY, as previously mentioned, can be converted into methionine by receiving a methyl group from 5-MTHF, or it can enter the transsulfuration pathway, where it is converted into cysteine

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In addition to these defining features, several histologic variants, such as gliosarcomas, giant-cell GBM, small-cell GBM, and epithelioid GBM, present distinct molecular and clinical implications

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