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doi: 10.1038/nrn.2017.48

The phase II study on ivaltinostat for advanced pancreatic ductal adenocarcinoma reports enhanced sensitivity of tumor cells to gemcitabine and erlotinib, presenting it as a potential treatment option

It is not a member of any cataloged peptide drug family with an approved indication

The reduced expression of HDAC11 leads to the increase in H3ac levels in the PAI-1 promoter and enhances PAI-1 expression, which aggravates I/R-induced inflammatory responses and kidney injury

Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity

2021 Dec 22;9(3):e0172521