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For this combination it identifies the shared pathways and shows exactly where the signals converge

These results collectively indicate that mitochondrial uncoupling with BAM15 has a powerful anti-obesity and insulin sensitization effect without affecting food intake

doi: 10.1016/0002-9378(89)90671-6 37 PlinerPFlemingAS

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Participants were randomized in a 2:1:1:1:1:2:2 ratio to once-weekly subcutaneous retatrutide at 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, over a 48-week treatment period