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Lancet 2013;381:117124 [DOI] [PubMed] [Google Scholar] 39.Heile M, Wyne K, Billings LK, Cannon A, Handelsman Y, Shannon M

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Depressed patients are often characterized by elevated blood cortisol levels and changes in the circadian secretion of this hormone, an increased number of corticotropin-releasing hormone (CRH)-expressing neurons in the hypothalamic paraventricular nucleus (PVN), as well as an impairment in a negative feedback mechanism, which can be measured in the dexamethasone suppression test [70, 71]

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