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This global initiative reframed obesity as a chronic, systemic disease rather than a mere risk factor

Patients with genetic markers suggesting heightened mood sensitivity receive enhanced monitoring, mental health referrals, and dose-adjustment strategies tailored to their molecular profile

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This broad pleiotropy was supported by associations observed in the 23andMe database (Supplementary Table 19)

In other words, treating an adolescents obesity can improve their overall health now and in the future because obesity increases the risk of serious health problems, including cardiovascular disease, hypertension (high blood pressure), diabetes mellitus, and certain types of cancer