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Macronutrients, bile acids (BAs), and microbiota-derived compounds activate many of these GPCRs expressed by GLP-1 expressing cells (71)

The following strains were obtained from the Caenorhabditis Genetics Center (CGC): N2, CF1903 glp-1(e2144) , MT8186 mpk-1(oz140) , JK1466 gld-1(q485) , VC2182 spe-17(ok2593) , UP749 ksr-2(dx27) , VC3391 R06F6.8(ok1318) , TJ356 [ zIs356 (daf-16p::daf-16a/b::gfp + rol-6 )], CL2166 [ dvIs19 (pAF15 gst-4p::GFP::NLS )], DMS303 [nIs590 [ fat-7p::fat-7::gfp + lin15(+) ] V ] and CB3323 [ che-13(e1805) ]

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These findings raise important questions about why direct GLP-1R agonism is effective while DPP-4 inhibition is not, highlighting the need to better understand the underlying mechanisms involved in this intervention, and how this knowledge can be leveraged to refine and optimize therapeutic approaches for AUD