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Indications Severe acute pain (e.g., post-surgical, trauma) Chronic cancer pain or palliative care Adverse Effects / Risks Respiratory depression (life-threatening in overdose) Sedation, dizziness, constipation, nausea Tolerance, dependence, and misuse potential Drug Interactions Additive CNS/respiratory depression with benzodiazepines, alcohol, or other opioids Interaction with CYP3A4 inhibitors/inducers may alter levels Clinical Note for Pharmacists & Prescribers Reserve for patients who are opioid-tolerant or require strong analgesia Always monitor respiratory status & reassess pain control Counsel patients on safe use, storage, and risk of misuse #PainManagement #Opioids #ClinicalPharmacy #Hydromorphone #Pharmacology To view or add a comment, sign in Day 118 of #RISEChallenge Drug of the Day: Prucalopride Drug Name: Prucalopride Class: Selective 5-HT receptor agonist Mechanism of Action: Prucalopride stimulates serotonin (5-HT) receptors in the gastrointestinal tract, enhancing colonic peristalsis and promoting bowel movement

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Fluctuation may not be simply diurnal and patients may have functional hardships one month that seem to improve on their own the next month without apparent explanation

2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC)

Blood pressure decreases by an average of 5-10 mmHg systolic

Semaglutide is contraindicated in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, and during pregnancy or breastfeeding