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Patients should be closely monitored during and after injections, and given oral premedication to reduce the risk of these reactions

The oral absorption of MTX is rapid but incomplete due to factors like receptor saturation, the inhibitory effect of food on its absorption, and rapid metabolization by gut flora (Attwa et al

This process facilitates the efficient clearance of NETs and their associated microorganisms, effectively curbing excessive inflammation and mitigating potential tissue damage