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showed that hyaluronic acid-coated, mannan conjugated MnO 2 NPs not only increased tumor oxygen levels in murine breast cancer, but also turned pro-tumorigenic M2 macrophages in the surrounding tumor microenvironment into pro-inflammatory M1 macrophages and enhanced chemotherapeutic responses (Song et al., 2016)

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Among potentially modifiable risk factors, sleep disorders, including insomnia and obstructive sleep apnea, and shortened sleep duration, have been linked to AD [2,3,4,5,6,7,8,9,10,11,12,13]

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