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A summary of the potential perioperative improvements suggested can be found in Table 3

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Retatrutide's cardiovascular outcomes trial won't complete until 2027-2028, so actual event reduction hasn't been demonstrated yet despite superior risk factor improvements

Peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1), a master regulator of mitochondrial biogenesis, decreased but increased by dulaglutide in aged mice