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Cardiovascular Safety Heart rate increases of approximately 2-6 beats per minute have been observed with orforglipron across clinical trials, consistent with the class effect of GLP-1 receptor agonists

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Important safety considerations include the lack of data regarding GLP-1 use during pregnancy

PT-141 (Bremelanotide): An FDA-approved peptide that enhances libido and sexual function through melanocortin receptor activation in the central nervous system