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These genetic markers predict individual responsiveness to tirzepatide, semaglutide, and dual-compound protocols, enabling truly personalized medication selection

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The two Phase 3 trials of the higher-dose version compared the efficacy and safety of once-weekly semaglutide 7.2mg to semaglutide 2.4mg over 72 weeks and showed that individuals with obesity, with or without type 2 diabetes, lost around 3 percent more of their body weight

But as Kamat pointed out, the largest group taking these drugs today is younger, does not have diabetes, and has been invisible in the literature. Between December 2014 and June 2025, 38% of the people in the study received a GLP-1 prescription, while the other 62% received standard diet and exercise counseling