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Both hypothyroidism and hyperthyroidism can alter glucose metabolism, insulin sensitivity and the pharmacodynamics of diabetes mellitus medications
Yono M, Pouresmail M, Takahashi W, Flanagan JF, Weiss RM, Latifpour J (2005) Effect of insulin treatment on tissue size of the genitourinary tract in BB rats with spontaneously developed and streptozotocin-induced diabetes

Metabolism 2014, 63, 10221030

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No international regulatory body has approved retatrutide for any indication
