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Treatment of diet-induced obese mice systemically with a potent NNMT inhibitor significantly reduced body weight and white adipose mass, decreased adipocyte size, and lowered plasma total cholesterol levels

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Many of these agents are produced in vivo and may be extracted from animals or humans to prepare pharmaceutical compositions

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Unidentified environmental factors in the interplay with susceptibility genes trigger events causing inflammatory demyelination, axonal injury, and neurodegeneration

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