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Furthermore, most data are derived from acute or subchronic interventions, and the long-term effects of GLP-1R agonism in the context of chronic opioid exposure remain largely uncharacterized

Larger, more rigorously designed studies are needed before these findings alter clinical practice, she said

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Fatigue is actually listed as a common adverse reaction in the Summary of Product Characteristics (SmPC) for some GLP-1 receptor agonists, particularly those used at higher doses for weight management such as semaglutide 2.4mg (Wegovy) and liraglutide 3mg (Saxenda)

Instead of three large meals, try four or five smaller snacks throughout the day