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10.3389/fnins.2022.970925 [DOI] [PMC free article] [PubMed] [Google Scholar] 23.Halloum W, Dughem YA, Beier D, Pellesi L (2024) Glucagon-like peptide-1 (GLP-1) receptor agonists for headache and pain disorders: a systematic review

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The adverse effects of GLP-1RA, such as nausea, constipation, and diarrhea, are thought to be the result of the pharmacological action of GLP-1, but the mechanisms have not been fully elucidated
[184].Novo Nordisk A/S, Novo Nordisk Annual Report 2015, 2016
6 GLP-1RA medications may also alter molecular pathways such as phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) or cyclic adenosine monophosphate (cAMP) dependent signaling pathways

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