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Strengths and limitations The study relies on a large sample and covers a full decade

Transgender youth reported using cigarettes at 4x the rate of cisgender youth

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In contrast, TVEM is able to capture temporal changes over time because the only restriction it imposes is that change over time in the coefficient curves (intercept and effects of covariates) is smooth (Hoover et al., 1998

This may require removal of the affected body part (amputation)

Clonidine or dexmedetomidine may be used to treat breakthrough agitation