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Chronic training stress depletes the raw material your brain needs to produce it

Scalabrino G, Veber D, Tredici G (2014) Relationships between cobalamin, epidermal growth factor, and normal prions in the myelin maintenance of central nervous system

Cysteine deprivation induces GCLM expression in hepatocytes, which was thought to facilitate holoenzyme formation and improve enzyme efficiency (Lee et al., 2006)

NRF2 KD , GPX2 KD , and NOTCH3 KD cell lines were established using lentiviral infection

The hormones, cytokines, and growth factors were also significantly decreased (Table 1)

Transforming growth factor-3 (TGF-3) exerts a protective effect on hippocampal neurons by binding to the TGF- type receptor I (TGF-RI), this neuroprotective effect is mediated by activation of the nuclear transcription factor 2 (Nrf-2)/Kelch-like ECH associated protein 1 (KEAP1)/hemo oxygenase 1 (HO-1) pathway, which strengthens the antioxidant defense and supports neuronal survival [44]