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Notably, ncr-1(0) mutants displayed an impaired increase in the number of synapses in high cholesterol (Fig 1K and L), suggesting that NCR-1mediated cholesterol absorption is required for the formation of more synapses under high-cholesterol conditions

Restor Neurol Neurosci 28:817824

Given these potentially beneficial effects on lipid metabolism, it is possible that thyroid hormone analogues and/or mimetics might be useful for the treatment of metabolic diseases involving the liver, such as hypercholesterolaemia and NAFLD

In all, a grand total of 573 ions were imaged for each individual tissue

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