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There was no apparent effect of renal impairment, hepatic impairment or upper GI disease on the PK and tolerability of orally administered semaglutide, suggesting that dose adjustment is not necessary in these special populations [11, 31,32,33]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Non-arteritic anterior ischemic optic neuropathy in an otherwise healthy young adult patient treated with liraglutide and semaglutide for weight loss: a cautionary tale

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These changes reflect the medication's effect on hepatic glucose production, insulin secretion, and lipid metabolism
