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In diabetes, this rapid inactivation contributes to reduced overall action

By synthesizing transcriptomic, pharmacokinetic, signaling, and pharmacovigilance findings into a coherent mechanistic framework, this narrative review addresses an unrecognized area of GLP-1 biology and provides the first integrated hypothesis on how prolonged GLP-1R activation could disrupt salivary gland function

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4.4 Oxyntomodulin and natural dual agonism Oxyntomodulin, a peptide derived from the proglucagon gene alongside GLP-1 and glucagon, provides a compelling example of endogenous polypharmacology

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