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Them2 also regulates muscle-to-organ crosstalk by controlling multiple myokine genes expression depending on dietary conditions, therefore Them2 may coordinate metabolism of fatty acids in the skeletal muscle, adipose tissue, and the liver [] [Figure 8b]

Bernier-Villamor et al., 2004a,b

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Am J Pathol 185:13961408

Gut microbiota in cancer immune response and immunotherapy

pneumoniae infection, the peripheral blood CD4+ T count is decreased, however, the ratio of T-lymphocytes to CD4+/CD8+ cells in the bronchoalveolar lavage fluid increases, possibly due to abundant CD4+ T cells being involved in the inflammatory reaction (54)