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Some patients on GLP-1 medications notice they feel calmer or less driven by food cravings

Depending on the dose that someone is giving themselves, they could experience some significant side effects, Pritchard said

Dont forget to adjust your caloric intake after every 510 pounds lost, as the calorie deficit needed at your starting weight may no longer apply

They recommend starting Ozempic at a low dose (0.25 mg once weekly for the first 4 weeks) for better tolerability

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Combining retatrutide with other agents that affect gut motility, such as opioids or anticholinergic drugs, could worsen these effects or alter the absorption of orally administered medications