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Healthcare providers are encouraged to evaluate each patients unique needs and discuss the potential benefits and limitations of each medication

The videos did not follow the FDAs advice from May 3, 2024, in which it recommended including disclosure about gastrointestinal adverse reactions associated with Zepbound

As a GIP/GLP-1 receptor agonist, tirzepatide enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying

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However, development of GIPR- and GCGR-based therapeutics has encountered drawbacks due to the complexity of physiology associated with GIP and GCG 4,5,6

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