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Lipopolysaccharides-mediated increase in glucose-stimulated insulin secretion: involvement of the GLP-1 pathway

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Ser17 of GLP-1 forming hydrogen bonds with Arg299 and Tyr205

In addition to providing a pharmacokinetic profile that enables once-weekly dosing, the acylation moiety of tirzepatide also contributes to the interaction with both the GIPR and GLP-1R, as well as possibly the cell membrane 50