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By day's end, smoking is more often for relieving symptoms of withdrawal than for providing pleasure and arousal

Interestingly, mitochondria have their own genome (mitochondrial DNA (mtDNA)) and mtDNA gene expression changes have been identified in smokers: a comparative analysis showed that 32 out of 37 mitochondrial genes were upregulated in smokers with normal lung function, nine of which were shared in vapers, indicating an important involvement of mitochondrial genes in the cellular response to smoking [33]

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Relating Science and Technology to Society and the Environment Why do you think vaping has become so popular so quickly