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Several physiological and psychological factors may potentially explain why some patients report mood changes or irritability while taking tirzepatide, even without established direct pharmacological effects on mood regulation

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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Neil PM, Aroda VR, Astrup A, et al

There were 93 patients (0.12%) with other optic nerve disorders in the semaglutide or tirzepatide group and 54 patients (0.07%) with other optic nerve disorders in the matched comparison group (hazard ratio, 1.65 [95% CI, 1.18-2.31])