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Consistent data on long-term use in children are limited, though adult studies report discontinuation rates between 37% and 81% at one year due to factors like cost, insurance, comorbidities, and absence of type 2 diabetes [83,84,85]

43 In the STEP 1, 3, 4 and 8 trials (the 68week long trials in participants without diabetes), weight loss of 5% (a threshold widely accepted as indicating clinically meaningful response to therapy) 46 was achieved by 86%89% of participants receiving semaglutide 2.4 mg versus 29%48% receiving placebo (Table 2)

After reconstitution with bacteriostatic water, refrigerate at 28C and use within 28 days

Some individuals may also experience loss of appetite , fatigue , or mild stomach discomfort

Both tirzepatide and semaglutide can be used at lower doses for long-term weight maintenance, helping you sustain your progress while continuing to enjoy other health benefits

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