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These medicines are made under strict controls and are studied in large clinical trials for both safety and effectiveness
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Any unexplained, persistent tachycardia (heart rate increase of 1020 beats per minute has been observed in clinical trials) should be evaluated

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In Phase 3 TRIUMPH-4, retatrutide at 12 mg produced 28.7% body weight loss at 68 weeks vs 2.1% for placebo

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