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Among the top 12, the biggest climbers were AstraZeneca, Eli Lilly, and Novo Nordisk

60 In a phase 2 trial of individuals with alcohol use disorder, semaglutide reduced alcohol consumption during a laboratory self-administration task (standardized regression coefficient []: 0.48, 95% CI 0.85, 0.11) and lowered both drinks per drinking day (: 0.41, 95% CI 0.73, 0.09) and weekly alcohol craving scores (: 0.39, 95% CI 0.73, 0.06) compared to placebo

The only interaction of concern is pharmacokinetic: the delayed gastric emptying affecting oral hormone absorption

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Preclinical research suggests GLP-1 receptor activation may reduce neuroinflammation, decrease amyloid-beta accumulation, enhance synaptic plasticity, and improve brain glucose metabolism