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10.1038/s44355-025-00030-2 140 VendrellJ.El BekayR.PeralB.Garcia-FuentesE.MegiaA.Macias-GonzalezM.et al (2011)

[DOI] [PubMed] 33.Chapman M.B., Norwood D.A., Price C., Abdulhadi B., Kyanam Kabir Baig K., Ahmed A.M., Peter S., Routman J.S., Snchez-Luna S.A., Duggan E.W., et al

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At 26 weeks, the mean weight loss was 8.6% in the 12 mg orforglipron group, 11.2% in the 24 mg orforglipron group, 12.3% in the 36 mg orforglipron group and 12.6% in the 45 mg orforglipron group compared with 2% for those receiving placebo

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The body recognizes that they belong. While we dont yet know the exact mechanism, one likely explanation is that estrogens ability to improve insulin sensitivity plays a role, says Dr
