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The difference seems to be that berberine increases high-glucose dependent insulin , [6,25] meaning that it's more effective when glucose is present

What about other SURPASS trials

These findings are likely true for Ozempic and other GLP-1 agonists

Weeks 1 to 2: With GLP-1 agonists, appetite reduction is usually noticeable within the first week

They are multi-system agents targeting seven of the eight known contributors to insulin resistance simultaneously