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f-j , Volcano plot of metabolic differences ( f) and levels of GSSG (g) , ophthalmic acid (h) , glutamate (i) , cysteine (NEM-cysteine) (j) from Gclc WT and Gclc KO tumors

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Hormonal cascades, sleep-wake cycles, and immune signals begin to drift out of sync, contributing to everything from metabolic dysfunction to neurodegeneration

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