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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Agers H, Jensen LB, Elbrnd B, Rolan P, Zdravkovic M

However, semaglutide is normally a self-administered injection, which can be a deterrent for many people

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Real-world reports show wide variability: some observational analyses note that about 5% experience sleep disturbances, while a 2025 Care Pharmacy summary found that roughly 30% of patients on Wegovy reported insomnia

Contrave uses a central nervous system approach via naltrexone and bupropion to suppress appetite signals in the brain

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