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If topiramate must be used, consider reducing the use of other CNS-active medications that increase the risk of falls and fractures and implement strategies to reduce fall risk

Never double-dose or inject twice in one week to make up for a missed dose, as this increases side effect risk without improving efficacy

Non-surgical interventions were of primary interest for the NMAs

However, the surge in clinical demand necessitates highly efficient, scalable, and robust production and purification frameworks to ensure product purity and patient safety