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Body weight reduction remains an important challenge in patients with T2D, as it requires changing their overall metabolic control
Retatrutides main complaints are GI-related (nausea, diarrhea, constipation) because it affects the gut
In VESPER-2 (weekly dosing in adults with obesity/overweight and type 2 diabetes), Pfizer reported dose-dependent reductions in body weight and HbA1c, including a 2.2% HbA1c reduction at week 28 with 1.6 mg weekly berobenatide (on-treatment estimand) versus 0.2% with placebo
The amounts vary based on the dose you take and how long you use the medication
The ASCO 2026 data does not support starting a GLP-1 medication in someone at a healthy weight for cancer prevention alone
