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Gastrointestinal events occurred most frequently during the dose escalation period and typically improved with continued treatment

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However, these studies found no significant improvements in a range of safety endpoints for cardiovascular diseases ( The Role of DPP-4 Inhibitors in Hypertension The first DPP-4 inhibitor, sitagliptin, was approved as an anti-hyperglycemic agent for T2DM in the United States of America in 2006

Jensen et al., 2012

With increasing concern over adverse events across the class, liver safety, cardiovascular outcomes, PK and PD stability, and dose optimized adherence will decide which assets rise to best in class status

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