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Increased demand for NAD+ relative to ATP drives aerobic glycolysis

Mouse CD38-specific heavy chain antibodies inhibit CD38 GDPR-cyclase activity and mediate cytotoxicity against tumor cells

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Metformin-related vitamin B12 deficiency occurs as metformin causes reduced vitamin B12 absorption by interfering with the vitamin B12-intrinsic factor complex

It has been suggested that increased matrix metalloproteinase (MMPs) activity in hypertension results in the proteolytic cleavage of the extracellular IGF-1R subunit and the observed lack of receptor sensitivity (19)