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doi: 10.1001/jamapsychiatry.2014.2502

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Strength training acts as a signal to the body to preserve musculature, while a sufficient protein intake provides the amino acids required to maintain and repair muscle tissue

Pratley R, Amod A, Hoff ST

All patients received medical, surgical, psychiatric, and nutritional evaluation and counseling
Not as a failure of the first drug but as a logical progression as obesity medicine gives patients better and better options
