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This sustained-release pattern from weekly injections allows smaller total doses to produce comparable or stronger therapeutic effects than daily oral tablets, which is why injections often outperform oral formulations in clinical trials measuring weight loss and glucose control

All GLP-1 Medications Share Similar Concerns The fundamental issue is slowed gastric emptying, which all GLP-1 medications cause

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As your body adapts to the medication over weeks or months, your appetite-suppressing response may gradually decreasea process called tachyphylaxis