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Both medications have similar digestive side effects, and the better option depends on treatment goals, tolerance, and medical guidance

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More recently, GLP-1 RA drugs have been approved for weight loss, cardiovascular disease, and chronic kidney disease

Nevertheless, the available data suggest that retatrutide may induce greater average weight loss than tirzepatide: Retatrutide (Triple G) In the TRIUMPH 4 trial, participants lost an average of 28.7% of body weight at 68 weeks at the 12 mg dose

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