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Importantly, they can also convert indigestible carbohydrates into short-chain fatty acids (SCFA), which in turn activate specific G protein-coupled fatty acid (FFA) receptors, thereby promoting the secretion of peptide hormones from the enteroendocrine cells [106, 107]

Based on the encouraging efficacy of GLP-1/glucagon and GLP-1/GIP co-agonists, it was rationalized that a single molecule with triple agonism at all three of these receptors might provide even greater efficacy than the respective co-agonists

ESSENCE Phase 3 semaglutide in MASH data supported FDA approval in March 2024 , creating a premium pricing tier in a disease category with USD 17.4 billion addressable market and no prior approved pharmacotherapy

GLG retrieved the main articles included in the review

GLP-1 companion products are an emerging category in this space

1 GLP-1 drugs have become increasingly popular in recent years