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Bernal-Orozco MF, Vizmanos B, Fau - Hunot C, Hunot C, Fau - Flores-Castro M, Flores-Castro MF, Leal-Mora D, Leal-Mora D et al

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Our recent SNO-proteome analysis of the cortices of Shank3 InsG3680 (+/+) mutant mice showed that several mitochondrial processes, including the ATP metabolic process, transmembrane electron transport, and the cellular response to oxidative stress, were SNO-enriched [64]

Values are mean SEM

Exploring small-molecule ligands has diversified targeted delivery with LNPs

These doses are 7 times and 4 times the maximum recommended human dose calculated on a body surface area basis using total mg/m 2 /week in rodents and mg/m 2 /week for a 50 kg human