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Description
These gastrointestinal side effects are typically worse when starting treatment or after a dosage increase, but usually subside as the body adjusts to the medication within 4-8 weeks

Luo X, Hu Y, He S, Ye Q, Lv Z, Liu J, Chen X

(A) Activation of SIRT by activator leads to deacetylation of Lys48 residues on LKB1

Proceedings of the National Academy of Sciences

The most frequent side effects are nausea, diarrhea, and mild stomach pain

Orexigenic neurons, which stimulate appetite, produce neuropeptide Y (NPY) and agouti-related peptide (AgRP)
