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In an evidence-based approach, the key points contributing to this consensus with respect to the clinical impact and benefits of GLP-1 RAs and their use in special populations are as follows: Clinical impact of GLP-1 RAs: GLP-1 RAs improve glucose homeostasis by enhancing glucose-dependent insulin secretion, by suppressing inappropriately elevated glucagon levels, both in fasting and postprandial states (Grade A

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doi: 10.1016/S2213-8587(21)00002-4 3 BellisSAKuhnIAdamsSMullarkeyLHollandA

The resulting effects of these medications on a patients physiology may influence clinical management decisions when optimizing a patient for sedation or general anesthesia

Moreover, continued investigation into the pleiotropic effects of GLP-1 receptor agonists may reveal other therapeutic possibilities, possibly transforming the management of many metabolic and non-metabolic disorders