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Heres how the authors explained this this: in the early stages of the disease, the gut makes a lot of GLP-1 to manage blood sugar

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The insulin spike from carbohydrates may slightly enhance creatine uptake into muscle cells, but more importantly, taking it with food reduces the chance of stomach upset

Current dual agonists under investigation also include efinopegdutide and cotadutide

This likely explains one of the mechanisms by which those with diabetes can see an improvement in sugar control

6 Since then, states have altered their positions on covering anti-obesity GLP-1 therapies: Four have withdrawn coverage entirely (California, New Hampshire, Pennsylvania, and South Carolina), three have added coverage (Missouri, Tennessee, and Utah), and at least two states (Michigan and Virginia) have enacted more narrow utilization criteria, limiting future use to those with morbid obesity