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On Tuesday, Frey, Maines attorney general, called the claims meritless and an attempt to intimidate proponents of the proposed shield law

5 Short-chain fatty acids (SCFAs) like butyrate are produced when gut bacteria ferment dietary fiber

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GLP-1 RAs have been shown to impact functions associated with metabolism and energy balance by delaying gastric emptying, reducing hunger, increasing postprandial satiety, and reducing ad libitum food intake.132134 In addition, GLP-1 activation in the CNS via the hypothalamus and medulla drives reduced appetite.135137 GLP-1 directly acts on pancreatic B-cells to increase insulin secretion and on hepatic cells to decrease glucagon excretion and regulate blood glucose levels, leading to reductions in body fat.138140 Liraglutide Liraglutide was developed by modifying GLP-1 protein to include a free fatty acid side chain bound to the peptide, allowing for albumin binding and (longer) half- allowing for daily dosing.142 Five randomized controlled trials of liraglutide in individuals with obesity have shown weight loss of 4.4 kg to 6.1 kg relative to placebo.63,64,143145 Semaglutide Semaglutide is a GLP-1 RA with significantly longer half-life supporting weekly SQ administration

The STEP 1 trial revealed that semaglutide led to greater reduction in fat mass than lean body mass, consistent with other weight loss interventions