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Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells

It is a type IV immune-mediated reaction mediated by cytotoxic T cells [63]

"Ozempic has become a leading, trusted brand for people with type 2 diabetes and the science is deep

and are approximately 1.5 times more likely to develop MS (7), with longer duration and poorer glycemic control conferring greater risk

A weight loss 5% occurred in 54.3, 40.4, and 21.4% of patients, respectively, and a weight loss 10% occurred in 25.2, 15.9, and 6.7% of patients, respectively

The REDEFINE 2 trial examined the combination in adults with type 2 diabetes, where weight loss is typically harder to achieve due to insulin resistance and medication effects