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Semaglutide and GLP-1 signalling are also linked to systemic and cellular immune modulation (including macrophage and T-cell signalling effects) and measurable anti-inflammatory biomarker reductions in clinical studies and meta-analyses

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Key Takeaways Ultimately, tirzepatide promotes a higher level of weight loss, but also typically results in slightly more severe side effects

For people whose sleep apnea is severe enough to affect daily functioning, the greater weight loss from tirzepatide or potentially retatrutide could be a deciding factor in medication choice