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In primary cultured chondrocytes, the mRNA expression of IL-6 induced by LPS or TNF- was significantly inhibited by GLS oil treatment (70)
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M2 macrophages are characterized by the most efficient phagocytosis and their involvement in tissue remodeling, immune regulation and tumor promotion (13, 26, 27, 33, 34)
Initial effectiveness data for APHD-012 is expected by the end of 2024 following the completion of phase 2 trials

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